hrp0082p1-d2-31 | Autoimmune Endocrine Disease | ESPE2014

Primary Pancreatic Insulinomas: Clinical, Morphological, and Genetic Characteristics of 12 Children

Melikyan Maria , Gurevich Larisa , Makarov Sergey , Stepanov Alexey , Friis-Hansen L , Peterkova Valentina , Christesen Henrik

Background: Insulinomas are extremely rare tumors in children and an uncommon first manifestation of the MEN1 syndrome. An early clinical and genetic diagnosis is very important for the appropriate medical assessment and family counseling. In children, insulinomas are usually benign tumors with only a few reports of malignant cases.Objective and hypotheses: To investigate clinical features, genetic and morphological characteristics of 12 children with pr...